Israel's new ultra-nationalist foreign minister Avigdor Lieberman has said it is not bound by a US-sponsored 2007 agreement to reach a peace deal with the Palestinians.
"The Annapolis conference, it has no validity," said in his first speech since taking office.
He was speaking at a handover ceremony at the foreign ministry, prompting his predecessor Tzipi Livni to interrupt and diplomats to shift uncomfortably.
The Annapolis process was meant to lead to the creation of a Palestinian state.
Palestinian leaders say Mr Lieberman's stance could undermine stability.
"There is one document that obligates us - and that's not the Annapolis conference, it has no validity," Mr Lieberman said.
11 hours ago